incidence of peioperative neurocognitive impairment
Effects of S-ketamine and Continuous Iliac Fascia Space Block on Perioperative Neurological Cognitive Impairment and Postoperative Rehabilitation in Elderly Patients With Hip Fracture
Brief Summary
Intervention / Treatment
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S-ketamine (DRUG)S-Ketamine0.1mg/kg was injected intravenously during anesthesia induction and S-Ketamine0.1mg/ (kg.h) was injected intravenously during anesthesia maintenance.S-Ketamine was put into the analgesia pump as an adjuvant for continuous analgesia until 2 days after operation.
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Continuous iliac fascia space block (DEVICE)After admission, the iliac fascia space block and catheterization were performed under the guidance of ultrasound, and the analgesia was continued until two days after operation.
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Normal saline (DRUG)Normal saline0.1ml/kg was injected intravenously during anesthesia induction and Normal saline0.1ml/ (kg.h) was injected intravenously during anesthesia maintenance.Normal saline was put into the analgesia pump as an adjuvant for continuous analgesia until 2 days after operation.
Condition or Disease
- Hip Fractures
Phase
Study Design
Study type: | INTERVENTIONAL |
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Status: | Recruiting |
Study results: | No Results Available |
Age: | 65 Years to 85 Years |
Enrollment: | 108 (ESTIMATED) |
Allocation: | Randomized |
Primary Purpose: | Treatment |
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Clinical Trial Dates
Start date: | Mar 26, 2022 | ESTIMATED |
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Primary Completion: | Apr 26, 2022 | ESTIMATED |
Completion Date: | Jan 31, 2023 | ESTIMATED |
Study First Posted: | Mar 31, 2022 | ACTUAL |
Last Updated: | Mar 27, 2022 |
Sponsors / Collaborators
Participant Groups
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S-ketamine 0.1mg/kg was injected intravenously during anesthesia induction and esmolamine 0.1mg/ (kg.h) was injected intravenously during anesthesia maintenance.S-Ketamine was put into the analgesia pump as an adjuvant for continuous analgesia until 2 days after operation.
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The hip fracture was diagnosed clinically on admission and ultrasound-guided iliofascial space block was performed after evaluation, and the analgesia lasted until 2 days after operation.
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normal saline 0.1ml/kg was injected intravenously during anesthesia induction and normal saline 0.1ml/ (kg.h) was injected intravenously during anesthesia maintenance.normal saline was put into the analgesia pump as an adjuvant for continuous analgesia until 2 days after operation.
Eligibility Criteria
Sex: | All |
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Minimum Age: | 65 |
Maximum Age: | 85 |
Age Groups: | Older Adult |
Healthy Volunteers: | Yes |
Clinical diagnosis of hip fracture
Aged 65 or above
ASA Ⅰ-Ⅲ
No mental and nervous system diseases
No pathological fractures, such as bone tumor, bone tuberculosis, osteomyelitis, etc
No puncture site infection
No hospital stay for more than 48 hours after operation
Exclusion Criteria:
Patients with severe cardiac, hepatic and renal dysfunction before operation
Long-term use of analgesics, sedatives and alcoholism
Patients with respiratory tract management difficulties (modified Ma's score is IV)
Previous neuropsychiatric diseases such as severe cerebrovascular, Alzheimer's disease, epilepsy and Parkinson's disease
Previous history of intracranial surgery or craniocerebral injury
Severe vision, hearing, language impairment or other reasons unable to communicate
Allergic or contraindicated to ropivacaine or non-steroidal anti-inflammatory drugs (NSAID)
Emergency surgery or trauma patients.
This clinical trial is recruiting
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Primary Outcomes
More Details
NCT Number: | NCT05304559 |
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Other IDs: | YShuang |
Study URL: | https://clinicaltrials.gov/study/NCT05304559 |