Impact of OFA During LPV on Postoperative Oxygen Saturation

Ketamine

Brief Summary

Opioids used intra operative increase the amount of opioids needed post operative to control post operative pain. if opioids are given post operative, we assume that more atelectasis and hypoxia takes place even after lung protective ventilation. These postoperative lower oxygen saturations will require giving more frequent oxygen therapy.

Intervention / Treatment

  • Opioid Anesthesia (PROCEDURE)
    opioid anesthesia means using sufentanil during surgery
  • opioid free anesthesia (PROCEDURE)
    opioid free anesthesia means giving no opioids during surgery

Condition or Disease

  • Decreased Lung Compliance
  • Oxygen Requirement

Phase

Study Design

Study type: OBSERVATIONAL
Status: Completed
Study results: No Results Available
Age: 18 Years and older   (Adult, Older Adult)
Enrollment: 64 (ACTUAL)
Funded by: Other
Time Perspective: Prospective
Observational Model: Cohort

Masking

Clinical Trial Dates

Start date: Aug 01, 2018 ACTUAL
Primary Completion: Oct 31, 2019 ACTUAL
Completion Date: Nov 05, 2019 ACTUAL
Study First Posted: Sep 06, 2018 ACTUAL
Results First Posted: Aug 31, 2020
Last Updated: Dec 01, 2019

Sponsors / Collaborators

Lead Sponsor: AZ Sint-Jan AV
Responsible Party: N/A

Location

Bruges, West Flanders, Belgium

This is an observational study where the attending anesthesiologist decides to use opioid free or opioid general anesthesia based on his/her expertise.

Every patient gets a lung protective ventilation and emergence from anesthesia using the principles set forward in the consensus meeting by Young C BJA 2019.

A lung recruitment followed by high PEEP is given when lung compliance decreases below 40 ML/cmH20. The lowest oxygen saturation without adding oxygen therapy is noted post extubation at moment of admission in PACU, after having given an opioid as analgesic and at moment of discharge from PACU..

If post operative satuation drops below 94% oxygen therapy is given and noted.

Participant Groups

  • classical anesthesia using sufentanil to block sympathetic reactions during surgery. This decision is based on the anesthesiologist experience and not determined by the patient or procedure.

  • anesthesia using non opioids like dexmedetomidine, lidocaine, magnesium and ketamine to block sympathetic reactions during surgery. This decision is based on the anesthesiologist experience and not determined by the patient or procedure.

Eligibility Criteria

Sex: All
Minimum Age: 18
Age Groups: Adult / Older Adult
Healthy Volunteers: Yes

Inclusion Criteria:

* major surgery where intubation with mechanical ventilation is required
* obese patients with BMI \> 35

Exclusion Criteria:

* spontaneous breathing during procedure
* allergic to any of the drugs used in both groups
* severe liver, renal, cardiac or pulmonary disease

Primary Outcomes

  • oxygen saturation

Secondary Outcomes

  • postoperative pain measured by VAS score

  • postoperative opioid consumption measured by morphine equivalents

More Details

NCT Number: NCT03660306
Other IDs: OS impact OFA on SAT d LPV
Study URL: https://clinicaltrials.gov/study/NCT03660306
Last updated: Sep 29, 2023