Mean arterial blood pressure measured by invasive transducer attached to arterial catheter
Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock
Brief Summary
Intervention / Treatment
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Ketamine (DRUG)After fluid resuscitation, patients will receive :1 mg/Kg ketamine + 0.5 ug/Kg fentanyl + 0.05 mg/Kg midazolam for induction of anesthesia
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Thiopental (DRUG)After fluid resuscitation, patients will receive :2 mg/Kg Thiopental + 0.5 ug/Kg fentanyl + 0.05 mg/Kg midazolam for induction of anesthesia
Condition or Disease
- Septic Shock
Phase
Study Design
Study type: | INTERVENTIONAL |
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Status: | Completed |
Study results: | No Results Available |
Age: | 18 Years and older (Adult, Older Adult) |
Enrollment: | 26 (ACTUAL) |
Funded by: | Other |
Allocation: | Randomized |
Primary Purpose: | Treatment |
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Clinical Trial Dates
Start date: | Apr 12, 2017 | ACTUAL |
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Primary Completion: | Apr 01, 2018 | ACTUAL |
Completion Date: | Apr 15, 2018 | ACTUAL |
Study First Posted: | Apr 07, 2017 | ACTUAL |
Results First Posted: | Aug 31, 2020 | |
Last Updated: | Jul 07, 2018 |
Sponsors / Collaborators
Location
In this study, patients with severe sepsis or septic shock scheduled for surgery will be assigned to receive either ketamine or thiopental for induction of anesthesia. After induction of anesthesia, endotracheal tube will be inserted aided by succinyl choline. Invasive blood pressure will be monitored through a transducer connected to arterial catheter. Electrical velocimetry (cardiometry) device will be used for non-invasive monitoring of cardiac output and stroke volume.
Participant Groups
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This group of patients will receive: 1 mg/Kg ketamine + 0.5 ug/Kg fentanyl + 0.05 mg/Kg midazolam for induction of anesthesia. Endotracheal tube will be inserted aided by 1 mg/Kg succinyl choline. Patients will undergo surgical procedure to eliminate the source of sepsis e.g. abdominal exploration. Invasive blood pressure monitor will be connected to the patient through an arterial catheter. Electrical velocimetry (cardiometry) device will be connected to the patient to measure cardiac output, stroke volume, and systemic vascular resistance.
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2 mg/Kg thiopental + 0.5 ug/Kg fentanyl + 0.05 mg/Kg midazolam for induction of anesthesia. Endotracheal tube will be inserted aided by 1 mg/Kg succinyl choline. Patients will undergo surgical procedure to eliminate the source of sepsis e.g. abdominal exploration. Invasive blood pressure monitor will be connected to the patient through an arterial catheter. Electrical velocimetry (cardiometry) device will be connected to the patient to measure cardiac output, stroke volume, and systemic vascular resistance.
Eligibility Criteria
Sex: | All |
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Minimum Age: | 18 |
Age Groups: | Adult / Older Adult |
Healthy Volunteers: | Yes |
* Sepsis patients with shock index (heart rate divided by systolic blood pressure) \>0.7. or Sepsis patients with norepinephrine infusion.
Exclusion Criteria:
* Traumatic brain injury
* Cerebrovascular disorders
Primary Outcomes
Secondary Outcomes
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cardiac output measured in litres per minute measured by electrical velocimetry
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cardiac stroke volume in milliliters measured by electrical velocimetry
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heart rate measured in beat per minute
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serum lactate measured in mmol/liter
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total dose of norepinephrine measured in micrograms
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the concentration of inhalational anesthetic (%)
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The percent of patients with severe hypotension after induction of anesthesia requiring stoppage of inhalational anesthesia
More Details
NCT Number: | NCT03104140 |
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Other IDs: | N-22-2017 |
Study URL: | https://clinicaltrials.gov/study/NCT03104140 |