Efficacy Study Comparing Compounded Topical Pain Creams vs. Placebo for Treating Pain Symptoms
Brief Summary
The main objective of this protocol is to determine the effectiveness of using compounded topical pain creams for treating neuropathic, nociceptive, or mixed-pain syndromes. Since these compounded pain creams may be associated with burning or irritation at the application site, and possible systemic effects may present, the secondary objective is to determine the relative satisfaction with the creams. The investigators hypothesis is that the active pain creams may provide significant benefit compared to placebo cream.
3.1 Specific Aims
- Specific Aim 1 will determine pain relief following treatment with the appropriate (based on specified pain) compounded topical pain cream or a placebo cream. The investigators hypothesis is that the compounded topical pain creams will provide greater pain relief than placebo creams.
- Specific Aim 2 will measure the patient satisfaction with the cream (compound or placebo). The investigators hypothesis is that the compounded topical pain creams will improve patient satisfaction, while the placebo cream will not result in a change in patient satisfaction with their pain treatment.
Intervention / Treatment
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Other: Neuropathic pain cream
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Other: Nociceptive pain cream
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Other: Mixed pain cream
Condition or Disease
- Pain
Phase
Study Design
| Study type: | Interventional |
|---|---|
| Status: | Completed |
| Study results: | No Results Available |
| Age: | 18 Years to 90 Years (Adult, Older Adult) |
| Enrollment: | 399 () |
| Funded by: | U.S. Fed |
Masking |
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Clinical Trial Dates
| Start date: | Aug 05, 2015 | |
|---|---|---|
| Primary Completion: | Feb 28, 2018 | |
| Completion Date: | Feb 28, 2018 | |
| Study First Posted: | Jul 14, 2015 | |
| Results First Posted: | Aug 31, 2020 | |
| Last Updated: | May 28, 2019 |
Sponsors / Collaborators
Lead Sponsor:
N/A
Responsible Party:
N/A
In this study, the investigators are attempting to determine whether compounded topical pain creams are more effective than placebo; as well as measuring the subjects' satisfaction with the compounded pain creams. Three different compounded pain creams (specific to the type of pain being treated) will be used to examine effectiveness and satisfaction in treating neuropathic, nociceptive, or mixed pain syndromes. Up to 399 subjects will be randomized to receive a compounded pain cream or placebo. The type of pain cream to be used will be based on the subjects' pain diagnosis. Pain relief will be measured by a 0-10 Numeric Rating Scale and satisfaction by a 1-5 Likert Satisfaction Scale. The outcome measures will include a 'positive outcome' defined as a two point or greater reduction in average pain (as measured by a NRS) and a score of greater than 3 (on a 1-5 Likert scale measuring satisfaction) at 1-month. The investigators will use the Rand Corporation SF-36 to measure changes in health status during enrollment. Subjects who obtain benefit at 1-month will be followed at 3-months, while those who fail to obtain benefit (i.e., ≥ 2 point reduction in NRS with a greater than 3 Likert satisfaction score) will exit the study to receive alternative care. Patients will be given a pain diary so that their NRS can be calculated at follow up visits.
Eligibility Criteria
| Sex: | All |
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| Minimum Age: | 18 |
| Maximum Age: | 90 |
More Details
| NCT Number: | NCT02497066 |
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| Other IDs: | #412770-2 |
| Study URL: | https://ClinicalTrials.gov/show/NCT02497066 |
Last updated: Jan 27, 2021