The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers
Brief Summary
Aim of the present study is to investigate the neuronal correlates of self and of personal meaning as well as the role of the serotonin (5-HT) 2A receptor system in these processes using functional magnetic resonance imaging (fMRI) and psychometric and cognitive measures.
Condition or Disease
- Healthy
Phase
Study Design
| Study type: | Interventional |
|---|---|
| Status: | Completed |
| Study results: | No Results Available |
| Age: | 20 Years to 40 Years (Adult) |
| Enrollment: | 25 () |
| Funded by: | Other |
Masking |
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Clinical Trial Dates
| Start date: | Mar 15, 2022 | |
|---|---|---|
| Primary Completion: | Jan 16, 2022 | |
| Completion Date: | Jan 16, 2022 | |
| Study First Posted: | May 21, 2015 | |
| Results First Posted: | Sep 25, 2020 | |
| Last Updated: | Feb 01, 2016 |
Sponsors / Collaborators
Lead Sponsor:
N/A
Responsible Party:
N/A
Location
The present study aims at identifying the contribution of the 5-HT2A receptor system to the formation of self and personal meaning in normal and altered states of consciousness. Specifically, the effect of the 5-HT2/1/6/7 receptor agonist lysergic acid diethylamide (LSD) on self-consciousness, perception and the making of meaning will be assessed in 25 healthy subjects using a randomized, placebo-controlled, double blind, cross-over design. Furthermore, the contribution of the 5-HT2A receptor to these functions shall be assessed by pretreatment with the specific 5-HT2A antagonist ketanserin.
Eligibility Criteria
| Sex: | All |
|---|---|
| Minimum Age: | 20 |
| Maximum Age: | 40 |
More Details
| NCT Number: | NCT02451072 |
|---|---|
| Other IDs: | LSDPUK-126 |
| Study URL: | https://ClinicalTrials.gov/show/NCT02451072 |
Last updated: Mar 23, 2022