Ketamine Prevent POCD
Brief Summary
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent. In present study investigators hypothesized that low dose ketamine would prevent the cognition decline after orthopedic surgery in aged patients.
Condition or Disease
- Necrosis of Femoral Head
- Knee Osteoarthritis
Phase
Study Design
| Study type: | Interventional |
|---|---|
| Status: | Unknown status |
| Study results: | No Results Available |
| Age: | 60 Years and older (Adult, Older Adult) |
| Enrollment: | 484 () |
| Funded by: | Other |
Masking |
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Clinical Trial Dates
| Start date: | Sep 14, 2020 | |
|---|---|---|
| Primary Completion: | Sep 16, 2020 | |
| Completion Date: | Sep 16, 2020 | |
| Study First Posted: | Aug 19, 2014 | |
| Results First Posted: | Aug 31, 2020 | |
| Last Updated: | Aug 19, 2014 |
Sponsors / Collaborators
Lead Sponsor:
N/A
Responsible Party:
N/A
Location
Eligibility Criteria
| Sex: | All |
|---|---|
| Minimum Age: | 60 |
More Details
| NCT Number: | NCT02220400 |
|---|---|
| Acronym: | KPPOCD |
| Other IDs: | KPPOCD |
| Study URL: | https://ClinicalTrials.gov/show/NCT02220400 |
Last updated: Jun 17, 2022