Hyperalgesia and NMDA Receptor Antagonist

Ketamine

Brief Summary

NMDA receptor is administered and postoperative remote hyperalgesia is investigated.

Intervention / Treatment

  • Magnesium Sulfate (DRUG)
    magnesium sulfate is added to the patients
  • Ketamine (DRUG)
    ketamine is added to the patients.

Condition or Disease

  • Pain

Phase

  • Not Applicable

    • Study Design

    Study type: INTERVENTIONAL
    Status: Unknown status
    Study results: No Results Available
    Age: 18 Years to 85 Years
    Enrollment: 90 (ESTIMATED)
    Funded by: Other
    Allocation: Randomized
    Primary Purpose: Prevention

    Masking

    QUADRUPLE:
    • Participant
    • Care Provider
    • Investigator
    • Outcomes Assessor

    Clinical Trial Dates

    Start date: Mar 01, 2014
    Primary Completion: Jul 01, 2014 ESTIMATED
    Completion Date: Jul 01, 2014 ESTIMATED
    Study First Posted: Mar 14, 2014 ESTIMATED
    Results First Posted: Aug 31, 2020
    Last Updated: Mar 12, 2014

    Sponsors / Collaborators

    Lead Sponsor: Seoul National University Bundang Hospital
    Responsible Party: N/A

    NMDA receptor is adminstered and postoperative tertiary hyperalgesia is investigated.

    QST and pain measures for remote hyperalgesia are compared between control and magnesium or ketamine group.

    Participant Groups

    • magnesium is added perioperatively to those patients undergoing staged total knee arthroplasty and other surgeries.

    • ketamine is administered to those patients undergoing stated TKA and other operations.

    • normal saline (placebo) is administered to the patients.

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Maximum Age: 85
    Age Groups: Adult / Older Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * ASA1-2

    Exclusion Criteria:

    * contraindication to the study drugs

    Primary Outcomes

    • pain (QST and pain measures )until 1 month from the end of the operation

    More Details

    NCT Number: NCT02087202
    Other IDs: hyperalgesia
    Study URL: https://clinicaltrials.gov/study/NCT02087202
    Last updated: Sep 29, 2023