Study of NMDA Antagonists and Neuropathic Pain
Brief Summary
The aim of this study is to evaluate if memantine or dextromethorphan gave in relay to ketamine maintains or induces a decrease of pain intensity.
In clinical, after ketamine cure, clinicians have often difficulties to treat patients in order to maintain analgesia or suggest another treatment if analgesia induced by ketamine was not effective, which occurs in one quarter of patients. It will be very useful for monitoring of painful patients evaluate if memantine or dextromethorphan could be an effective therapeutic alternative in neuropathic pain treatment.
Intervention / Treatment
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Drug: Dextromethorphan (drug used like antitussive)
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Drug: Memantine (drug used in Alzheimer's disease)
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Drug: Placebo (lactose)
Condition or Disease
- Neuropathic Pain
Phase
Study Design
| Study type: | Interventional |
|---|---|
| Status: | Completed |
| Study results: | No Results Available |
| Age: | 18 Years and older (Adult, Older Adult) |
| Enrollment: | 7 () |
| Funded by: | Other |
Masking |
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Clinical Trial Dates
| Start date: | May 12, 2020 | |
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| Primary Completion: | Jun 14, 2020 | |
| Completion Date: | Sep 07, 2016 | |
| Study First Posted: | May 18, 2012 | |
| Results First Posted: | Aug 31, 2020 | |
| Last Updated: | Oct 11, 2017 |
Sponsors / Collaborators
The aim of this study is to evaluate if memantine or dextromethorphan gave in relay to ketamine maintains or induces a decrease of pain intensity.
In clinical, after ketamine cure, clinicians have often difficulties to treat patients in order to maintain analgesia or suggest another treatment if analgesia induced by ketamine was not effective, which occurs in one quarter of patients. It will be very useful for monitoring of painful patients evaluate if memantine or dextromethorphan could be an effective therapeutic alternative in neuropathic pain treatment.
Eligibility Criteria
| Sex: | All |
|---|---|
| Minimum Age: | 18 |
More Details
| NCT Number: | NCT01602185 |
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| Acronym: | NMDA |
| Other IDs: | CHU-0112 |
| Study URL: | https://ClinicalTrials.gov/show/NCT01602185 |