Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Brief Summary
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.
Condition or Disease
- Post Operative Pain
- Hyperalgesia
Phase
Study Design
| Study type: | Interventional |
|---|---|
| Status: | Unknown status |
| Study results: | No Results Available |
| Age: | 18 Years to 75 Years (Adult, Older Adult) |
| Enrollment: | 96 () |
| Funded by: | Other |
Masking |
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Clinical Trial Dates
| Start date: | Dec 09, 2020 | |
|---|---|---|
| Primary Completion: | Jun 12, 2020 | |
| Completion Date: | Aug 12, 2020 | |
| Study First Posted: | May 08, 2012 | |
| Results First Posted: | Aug 31, 2020 | |
| Last Updated: | May 16, 2012 |
Sponsors / Collaborators
Lead Sponsor:
N/A
Responsible Party:
N/A
Location
not desired
Eligibility Criteria
| Sex: | All |
|---|---|
| Minimum Age: | 18 |
| Maximum Age: | 75 |
More Details
| NCT Number: | NCT01594047 |
|---|---|
| Other IDs: | metadone |
| Study URL: | https://ClinicalTrials.gov/show/NCT01594047 |
Last updated: Jun 17, 2022