Escalating Ketamine Doses and Pre-emption

Ketamine

Brief Summary

Ketamine affects postoperative pain when administered intravenously immediately before, during or at the end of surgical procedures. We assessed the effects of multiple and escalating doses of ketamine administered many hours before surgery on postoperative pain and analgesia consumption.

Intervention / Treatment

  • Ketamine (DRUG)
    ketamine injected IM 17-18, 11-12, and 3-4 hours before surgery (5, 10 and 25 mg, respectively) (K3), and the second group received NS

Condition or Disease

  • Postoperative Pain Management

Phase

Study Design

Study type: INTERVENTIONAL
Status: Completed
Study results: No Results Available
Age: 15 Years to 75 Years
Enrollment: 120 (ACTUAL)
Funded by: Other
Allocation: Randomized
Primary Purpose: Treatment

Masking

Clinical Trial Dates

Start date: Jan 01, 2007
Primary Completion: Jan 01, 2009 ACTUAL
Completion Date: Jan 01, 2009 ACTUAL
Study First Posted: Feb 17, 2010 ESTIMATED
Results First Posted: Aug 31, 2020
Last Updated: Feb 16, 2010

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

Eligibility Criteria

Sex: All
Minimum Age: 15
Maximum Age: 75
Healthy Volunteers: Yes

Inclusion Criteria:

Consecutive patients, who were scheduled to undergo general or orthopedic oncologic surgery under general anesthesia

Exclusion Criteria:

1. allergy to opioids, ketamine or non-steroidal anti-inflammatory drugs (NSAIDs)
2. history of lasting chronic pain or psychiatric disorders or had used opioids or psychotropic drugs of any sort during the past two weeks
3. soldiers and pregnant women

Primary Outcomes
  • postoperative pain 48 hours
Secondary Outcomes
  • opioid drug consumption 48 hours

More Details

NCT Number: NCT01070108
Other IDs: ketamine
Study URL: https://clinicaltrials.gov/study/NCT01070108
Last updated: Sep 29, 2023