The Effects AZD8529 on Ketamine-induced Impairment of Working Memory in Healthy Volunteers

Ketamine

Brief Summary

The purpose of this study is to assess if ketamine will induce, in healthy volunteers, impairment of working memory and if the drug AZD8529 will block the effects of ketamine on working memory as assessed by functional magnetic resonance imaging (fMRI).

Intervention / Treatment

AZD8529 (DRUG)

6 capsules by mouth 1 time 12 to 24 prior to assessments
Placebo to match AZD8529 (DRUG)

6 capsules by mouth 1 time 12 to 24 hours prior to assessments

Condition or Disease

Healthy
Memory Impairment

Phase

Study Design

Study type:	INTERVENTIONAL
Status:	Completed
Study results:	No Results Available
Age:	21 Years to 45 Years
Enrollment:	20 (ESTIMATED)
Funded by:	Industry
Allocation:	Randomized
Primary Purpose:	Basic Science
Masking

Clinical Trial Dates

Start date:	Feb 01, 2010
Primary Completion:	Apr 01, 2011	ACTUAL
Completion Date:	Apr 01, 2011	ACTUAL
Study First Posted:	Sep 29, 2009	ESTIMATED
Results First Posted:	Aug 31, 2020
Last Updated:	May 03, 2011

Sponsors / Collaborators

Lead Sponsor: N/A

Responsible Party: N/A

Location

New Haven, Connecticut, USA

Eligibility Criteria

Sex:	All
Minimum Age:	21
Maximum Age:	45
Healthy Volunteers:	Yes

Inclusion Criteria:

* Right handed
* 12th grade education or equivalent
* Able to read and write English as primary language

Exclusion Criteria:

* History of head injury
* Substance abuse or dependence
* History of claustrophobia

Primary Outcomes

fMRI 3
Ketamine Infusion 3

Secondary Outcomes

Clinician Administered Dissociative States Scale (CADSS)
Positive and Negative Syndrome Scale (PANSS)
Laboratory assessment: electrocardiogram (ECG), physical exam, vital signs, collection of adverse events

More Details

NCT Number:	NCT00985933
Other IDs:	D2285M00015
Study URL:	https://clinicaltrials.gov/study/NCT00985933

Last updated: Sep 29, 2023