Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion

Ketamine

Brief Summary

Propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. Three different strategies to prevent propofol induced pain will be studied compared with placebo. Pain will be scored with a four-point scale.

Intervention / Treatment

kétamine 20mg (DRUG)

N/A
ephedrine 3mg (DRUG)

N/A
lidocaine 40mg (DRUG)

N/A

Condition or Disease

Induction of Total Intravenous General Anesthesia

Phase

Phase 3

Study Design

Study type:	INTERVENTIONAL
Status:	Unknown status
Study results:	No Results Available
Age:	18 Years to 75 Years
Enrollment:	200 ()
Funded by:	Other
Allocation:	Randomized
Masking

Clinical Trial Dates

Start date:	Sep 01, 2005
Primary Completion:	Aug 31, 2020
Completion Date:	Aug 31, 2020
Study First Posted:	Sep 07, 2005	ESTIMATED
Results First Posted:	Aug 31, 2020
Last Updated:	Apr 26, 2007

Sponsors / Collaborators

Lead Sponsor: Hospices Civils de Lyon

Responsible Party: N/A

No responsible party listed

Location

Lyon, Auvergne-Rhône-Alpes, France

Eligibility Criteria

Sex:	All
Minimum Age:	18
Maximum Age:	75
Age Groups:	Adult / Older Adult
Healthy Volunteers:	Yes

Inclusion Criteria:

Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol

Exclusion Criteria:

* pregnant
* sedative or analgesic drug 24h before surgery
* allergy with drug used in the study
* difficulty of communication
* absence of informed written consent

Primary Outcomes

After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness

Secondary Outcomes

Explicite and implicite memory of pain immediately after surgery and on day one
Adverse effects

More Details

NCT Number:	NCT00146926
Other IDs:	2004.367
Study URL:	https://clinicaltrials.gov/study/NCT00146926

Last updated: Sep 29, 2023