Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls

Ketamine

Brief Summary

This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.

Intervention / Treatment

  • Fentanyl (DRUG)
    N/A
  • S-ketamine (DRUG)
    N/A

Condition or Disease

  • Odontalgia

Phase

  • Phase 4

    • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 18 Years to 65 Years
    Enrollment: 20 ()
    Funded by: Other
    Allocation: Randomized
    Primary Purpose: Diagnostic

    Masking

    Clinical Trial Dates

    Start date: Mar 01, 2004
    Primary Completion: Aug 31, 2020
    Completion Date: Oct 01, 2005
    Study First Posted: Jun 21, 2005 ESTIMATED
    Results First Posted: Aug 31, 2020
    Last Updated: Jun 15, 2006

    Sponsors / Collaborators

    Lead Sponsor: University of Aarhus
    Responsible Party: N/A
    No responsible party listed

    Location

    Aarhus, Denmark

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Maximum Age: 65
    Age Groups: Adult / Older Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * Atypical odontalgia

    Exclusion Criteria:

    * BMI \> 30
    * Heart conditions
    * Lung disease
    * Diseases of the liver or kidneys
    * Hypertension, untreated

    Primary Outcomes
    • Pain
    • Sensitivity to heat and cold
    • Sensitivity to mechanical stimuli

    More Details

    NCT Number: NCT00115102
    Other IDs: AO1
    Study URL: https://clinicaltrials.gov/study/NCT00115102
    Last updated: Sep 29, 2023