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Clinical Trials

1,344 Clinical Trials

Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.

Completed
Major Depressive Disorder
Start Date: Aug 2020
Last Updated: May 2022
Zürich, Switzerland
GHB

Duration of Anaesthesia Induction in Paediatric Patients: Prospective Observational Trial

Completed
Anaesthesia Induction
Start Date: Oct 2020
Last Updated: Feb 2022
Ketamine

Imaging Neural Correlates of Ketamine Using PET/MR

Not yet recruiting
Major Depressive Disorder
Start Date: Oct 2020
Last Updated: Oct 2020
Ketamine

Memory Consolidation in Pharmacologically Enhanced Naps

Completed
Sleep
Start Date: Sep 2008
Last Updated: Jul 2021
La Jolla, California, USA
GHB

Modulation of CSF Amyloid-beta Concentrations Via Behavioral Sleep Deprivation and Pharmacological Sleep Induction

Completed
Amyloid-beta
Start Date: Dec 2013
Last Updated: Mar 2018
Saint Louis, Missouri, USA
GHB

Vital Capacity in Ultrasound Guided Serratus Plane Block in ED Patients With Multiple Rib Fractures

Recruiting
Pain
Start Date: Nov 2021
Last Updated: Dec 2022
Ketamine

Safety and Efficacy of Xyrem Oral Solution (Sodium Oxybate) Compared With Placebo in Narcoleptic Patients

Completed
Narcolepsy
Start Date: Dec 2000
Last Updated: Jun 2005
Vancouver, British Columbia, Canada / Montreal, Quebec, Canada / New York, New York, USA and 38 more
GHB

Towards a Post-exposition Pharmacological Prophylaxis for Post-traumatic Stress Disorder

Completed
Intrusive Thought
Psychological Trauma
Inflammatory Response
Physiological Stress
Start Date: Oct 2021
Last Updated: Oct 2022
Zürich, Switzerland
GHB

Intraperitoneal Dexmedetomidine Versus Ketamine With Bupivacaine For Postoperative Analgesia

Completed
Obesity
Start Date: Oct 2021
Last Updated: Apr 2023
Zagazig, Sharqia, Egypt
Ketamine

Intraoperative Lidocaine and Combined With Ketamine on Opioid After Bariatric Surgery

Active, not recruiting
Laparoscopic Bariatric Surgery
Start Date: Apr 2021
Last Updated: Apr 2022
Ketamine

Observational Study to Evaluate Risks of Side Effects, Drug Abuse and Dependence in Patients Who Received Xyrem ® on Prescription

Completed
Narcolepsy
Start Date: May 2006
Last Updated: Sep 2016
Dublin, Ireland / Berlin, Germany / Zürich, Switzerland and 33 more
GHB

Safety and Efficacy Study of Xyrem® (Sodium Oxybate) in Subjects With Fibromyalgia.

Completed
Fibromyalgia
Start Date: Dec 2006
Last Updated: Mar 2012
London, England, United Kingdom / Chicago, Illinois, USA / Austin, Texas, USA and 83 more
GHB

Sodium Oxybate in the Treatment of Binge Eating Disorder

Completed
Binge Eating Disorder
Start Date: Aug 2007
Last Updated: Jun 2011
Mason, Ohio, USA
GHB

Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor

Completed
Essential Tremor
Start Date: Dec 2007
Last Updated: Dec 2011
Bingham Farms, Michigan, USA
GHB

A Safety and Efficacy Study of Xyrem® (Sodium Oxybate) to Treat Fibromyalgia.

Completed
Fibromyalgia
Start Date: Dec 2006
Last Updated: Jan 2012
London, England, United Kingdom / Chicago, Illinois, USA / Arlington, Virginia, USA and 101 more
GHB

Patient Narcoleptic Treated With BF2.649 (Pitolisant) in add-on to Sodium Oxybate (HARMONY IV)

Completed
Narcolepsy
Start Date: Sep 2012
Last Updated: Nov 2015
Montpellier, Occitanie, France
GHB

An Open Label Study of FT218 in Subjects With Narcolepsy

Active, not recruiting
Narcolepsy
Cataplexy
Excessive Daytime Somnolence
Sleep Disorder
Sleep Disturbance
Sleep Wake Disorders
Start Date: Jun 2020
Last Updated: Jun 2022
Boulder, Colorado, USA / Atlanta, Georgia, USA / Santa Ana, California, USA and 10 more
GHB

Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients

Completed
Obstructive Sleep Apnea Syndrome
Start Date: Nov 2003
Last Updated: Jan 2012
London, Ontario, Canada / St. Petersburg, Florida, USA
GHB

Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure

Active, not recruiting
Blast or Combat Exposure
Head Injury Trauma
Start Date: Nov 2021
Last Updated: Aug 2023
Iboga

Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy

Completed
Narcolepsy
Start Date: Apr 2003
Last Updated: Dec 2011
Los Angeles, California, USA / San Antonio, Texas, USA / Zürich, Switzerland and 33 more
GHB

Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

Completed
Excessive Daytime Sleepiness
Cataplexy
Narcolepsy
Start Date: Nov 2016
Last Updated: Mar 2022
Montreal, Quebec, Canada / New York, New York, USA / Boulder, Colorado, USA and 50 more
GHB

Safety and Tolerability Study Comparing Sodium Oxybate Given as an Oral Solution to a Single-blinded Combination of Oral Tablets Plus Oral Solution in Subjects With Fibromyalgia

Completed
Fibromyalgia
Start Date: Mar 2010
Last Updated: Aug 2011
Austin, Texas, USA / Houston, Texas, USA / Sacramento, California, USA and 26 more
GHB

A Study of the Efficacy and Safety of JZP-258 in Subjects With Narcolepsy With Cataplexy

Completed
Narcolepsy With Cataplexy
Start Date: Mar 2017
Last Updated: Nov 2020
Boulder, Colorado, USA / Madrid, Spain / Stanford, California, USA and 21 more
GHB

Phase 1 Bioavailability Study of MELT-100 (Midazolam and Ketamine Sublingual) and IV Midazolam or Ketamine

Completed
Healthy Volunteers
Start Date: Jul 2020
Last Updated: Feb 2021
Ketamine

Ketamine Versus Dexmedetomidine in Supraclavicular Brachial Plexus Block

Completed
Supraclavicular Brachial Plexus Block
Start Date: Apr 2019
Last Updated: Jul 2023
Ketamine

Impact of Gamma-OH on Sleep in ICU Patients

Unknown status
Weaning From Mechanical Ventilation
Start Date: Jan 2020
Last Updated: Jan 2020
Poitiers, Nouvelle-Aquitaine, France
GHB

Sodium Oxybate in Patients With Chronic Fatigue Syndrome.

Withdrawn
Chronic Fatigue Syndrome
Start Date: Jun 2013
Last Updated: Dec 2022
Ghent, East Flanders, Belgium
GHB

Treatment of REM Sleep Behavior Disorder (RBD) With Sodium Oxybate

Completed
REM Sleep Behavior Disorder
Parkinson Disease
Start Date: Sep 2019
Last Updated: Apr 2023
Palo Alto, California, USA
GHB

Sodium Oxybate in Schizophrenia With Insomnia

Completed
Schizophrenia
Insomnia Related to Schizophrenia (307.42)
Start Date: May 2008
Last Updated: Jan 2016
Orangeburg, New York, USA
GHB

Evaluation of the Efficacy of Sodium Oxybate (Xyrem®) in Treatment of Post-traumatic Narcolepsy and Post-traumatic Hypersomnia

Withdrawn
Hypersomnia
Narcolepsy
Traumatic Brain Injury
Start Date: Sep 2020
Last Updated: Mar 2021
Boston, Massachusetts, USA
GHB

Comparative Study of Gamma-hydroxy Butyrate Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome

Completed
Alcohol Withdrawal Syndrome
Alcohol Dependence
Start Date: Feb 2002
Last Updated: Mar 2014
Vienna, Austria / Rome, Lazio, Italy / Bologna, Emilia-Romagna, Italy
GHB

Enhancing Slow Wave Sleep With Sodium Oxybate

Completed
Sleep
Start Date: May 2007
Last Updated: Sep 2008
Chesterfield, Missouri, USA
GHB

Sodium Oxybate in Idiopathic Hypersomnia

Completed
Idiopathic Hypersomnia
Start Date: Oct 2018
Last Updated: Sep 2023
Montpellier, Occitanie, France
GHB

The Effect of Sodium Oxybate on Sleep Architecture

Withdrawn
Mechanically Ventilated ICU Patients
Start Date: Oct 2008
Last Updated: Feb 2018
Boston, Massachusetts, USA
GHB

A Phase 1, Single Dose Study of JZP-386 to Evaluate Safety, Pharmacokinetics and Pharmacodynamics

Completed
Narcolepsy, Excessive Daytime Sleepiness
Start Date: Jul 2014
Last Updated: May 2015
Nottingham, England, United Kingdom / Ruddington, England, United Kingdom
GHB

Exploratory Clinical Study to Evaluate Sodium Oxybate (Xyrem) on Potential Endocrine Changes

Completed
Narcolepsy With Cataplexy
Start Date: Apr 2006
Last Updated: Feb 2022
Liège, Belgium
GHB